Contact information:

: christian.tshiongo@unikin.ac.cd; chri.muamba@gmail.com
: +243 81 350 9977
Faculty of Science Building, Office D13
av de l'Université - C. de Lemba - Kinshasa
Postal adress: P.O Box 190 Kin XI Kinshasa - DR Congo

Education

B.Sc. Faculty of Science, Université de Lausanne, Lausanne, Switzerland.
M.Sc. Faculty of Science, Université de Lausanne, Lausanne, Switzerland.
PhD Bio-organic Chemistry, Faculty of Science, Université de Lausanne, Lausanne, Switzerland.
Thesis title: Synthèse et études de la relation structure-activité (RSA) de dérivés antiviraux et hydrosolubles de la cyclosporine A, 2000.

Research interest

My research group is interested in the extraction, purification and structural analysis (spectroscopic and spectrometric) of natural products with biological activity. We also use study computational chemistry in order to determine Structure-Activity Relationship (SAR) and QRSA of identified and purified active ingredients

Key words: Carbohydrate chemistry, Peptide chemistry, Chromatography Techniques, NMR spectroscopy Mass Spectrometry.

Teaching

• Organic Chemistry
• Computational Chemistry
• Structure-Reactivity Relationship
• Proton and Carbon NMR

Scholarly Activity

Scholarly Societies membership

Effective members of several learned societies including Société de chimiste du Congo (Sochimico)

Patent

“Nouvelle cyclosporine ayant un profil d’activité amélioré” WO 00/01715.

Selected Articles

Hubler F., Ruckle T., Patiny L., Muamba T., Guichou J-F., Mutter M., “Synthetic routes to NetXaa4 -cyclosporin A derivatives as potential anti-HIV 1 drugs”, Tetrahedron Lett., 2000, 41, 7193-7196.

Hubler F., Muamba T., Guichou J-F., Brunner L., Mutter M., “Structure-based design of new cyclosporine analogues” oral communication, Paris, 2000, Peptide symposium on Chemoselective ligation.

Muamba T., Hubler, F., Guichou J-F., Patiny L., Ruckle, T., Mutter M., “New synthetic routes to NRXaa4 -cyclosporin derivatives as potential anti-HIV drugs”, 17th American Peptide Symposium, San Diego, June, 2001 (soumis).

Muamba T., Hubler F., Patiny L., Wenger R., Mutter M.; “Double-modified cyclosporin analogues as non-immunosuppressive, anti-HIV active agents: synthesis and biological evaluation” (résultats non publiés).

Kayembe J. S., Taba K. M., Ntumba K., Tshiongo M. T. C., and Kazadi K.; “In vitro anti-malaria activity of 20 quinones isolated from four plants used by traditional healers in the Demoncratic Republic of Congo; Journal of medicinal plants research; 2010, 4(11), 991-994.

Mfele N. J., Kazadi K.T., Ntumba K. J., Taba K. M., Tshiongo M.T.C.; “Antiplasmodial activity of the root bark of Strophanthus hispidus DC.”; Congo Sciences; 2021, 9(1).

Mfele N. J., Kilembe T. J., Ntumba K. J., Taba K. M., Tshiongo M.T.C.; “Synthèse, évaluation de l’activité antibactérienne et étude de la relation structure-activité des quelques analogues de l’ibuprofène”; Congo Sciences, 2022, (soumis)